Lifespan of neurons is uncoupled from organismal lifespan.

Double edged effect of gum-resin of ferula assa-foetida on lifespan of neurons

Wild-derived inbred mouse strains have short telomeres.

Telomere length and telomerase activity directly affect the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions in a number of inbred and outbred established mouse strains with those of strains recently derived from wild mice. Telomere length was considerably shorter in wild-derived strai...

Insulin/IGF-like signalling, the central nervous system and aging.

Enormous strides in understanding aging have come from the discovery that mutations in single genes can extend healthy life-span in laboratory model organisms such as the yeast Saccharomyces, the fruit fly Drosophila melanogaster, the nematode worm Caenorhabditis elegans and the mouse. IIS [insulin/IGF (insulin-like growth factor)-like signalling] stands out as an important, evolutionarily cons...

Ovulatory response of different GnRH analogues and subsequent corpus luteum lifespan in the presence of norgestomet in Holstein heifers

This study investigated the effect of GnRH analogues on inducing ovulation of dominant follicle (DF)and subsequent corpus luteum (CL) lifespan in the presence of norgestomet implant in Holstein heifers. Onday 6 to 8 of the estrous cycle (day 0 of the experiment), all heifers (n=15) received norgestomet implantfollowed by prostaglandin injection on days 0 and 1. On day 4, group 1 (n=4) and 2 (n=...

Autophagy drives epidermal deterioration in a Drosophila model of tissue aging

Organismal lifespan has been the primary readout in aging research. However, how longevity genes control tissue-specific aging remains an open question. To examine the crosstalk between longevity programs and specific tissues during aging, biomarkers of organ-specific aging are urgently needed. Since the earliest signs of aging occur in the skin, we sought to examine skin aging in a genetically...